Our research group is interested in the developments of novel mass spectrometry instruments, in particular those utilizing ion mobility separations. We use them in several applications in clinical and environmental research areas. Ion mobility mass spectrometry is a growing research area as the need for structural elucidation evidently is increasing rapidly. Our research is focused on rapid identification of infectious diseases by efficient discrimination of causing pathogens. This will eventually reduce the antibiotic resistance and increase recovery rates. Moreover, we are interested in direct detection of pesticides from crops. This will help the community in monitoring the levels of pesticides which will eventually cut the rates of unintentional poisoning. On the long term, we will work towards developing a portable ion mobility analytical device that can be used to diagnose infectious diseases and detect pesticides. Having such a device will enable non-expert users such as nurses and farmers to perform fast screening tests.

 Selected Publications

(Google Scholar: https://scholar.google.com/citations?user=EiRByScAAAAJ&hl=en&oi=ao)

1. Olajide, O. E.; Donor, B.; Hamid, A. M.* “Systematic Optimization of Ambient Ionization Ion Mobility Mass Spectrometry for Rapid Separation of Isomers”  J. Am. Soc. Mass Spec. 2022, 33, 1, 160-171. DOI: 10.1021/jasms.1c00311

2. Ibrahim, Y. M.; Hamid, A. M.; Deng, L.: Garimella, S. V. B.; Webb, I. K.; Smith, R. D. “New Frontiers for Mass Spectrometry based upon Structures for Lossless Ion Manipulations” Analyst 2017, 142, 1010-1021. DOI: 1039/C7AN00031F

3. Hamid, A. M.; Ibrahim, Y. M.; Garimella, S. V. B.; Webb, I. K.; Deng, L.; Chen, T-C.; Anderson, G. A.; Prost, S. A.; Norheim, R. V.; Tolmachev, A. V.; Smith, R. D. “Characterization of Traveling Wave Structures Ion Mobility Separations in Lossless Ion Manipulations” Chem. 2015, 87 (22), 11301-11308. DOI: 10.1021/acs.analchem.5b02481

4. Hamid, A. M.; Jarmusch, A. K.; Pirro, V.; Pincus, D. H.; Clay, B.; Gervasui, G.; Cooks, R. G. “Rapid Identification of Bacteria by Paper Spray Mass Spectrometry” Chem. 2014, 86(15), 7500–7507. DOI: 10.1021/ac501254b

5. Soliman, A. R.; Hamid, A. M.; Attah, I.; Momoh, P.; El-Shall, M. S. “Formation of Nitrogen-Containing Polycyclic Cations by Gas Phase and Intracluster Reactions of Acetylene with the Pyridinium and Pyrimidinium Ions” Am. Chem. Soc. 2012, 135, 155-166. DOI:10.1021/ja3068116